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High seroprevalence of Mycoplasma pneumoniae IgM in acute Q fever by enzyme-linked immunosorbent assay (ELISA).
[scrub typhus]
Q
fever
is
serologically
cross-reactive
with
other
intracellular
microorganisms
.
However
,
studies
of
the
serological
status
of
Mycoplasma
pneumoniae
and
Chlamydophila
pneumoniae
during
Q
fever
are
rare
.
We
conducted
a
retrospective
serological
study
of
M
.
pneumoniae
and
C
.
pneumoniae
by
enzyme-linked
immunosorbent
assay
(
ELISA
)
,
a
method
widely
used
in
clinical
practice
,
in
102
cases
of
acute
Q
fever
,
39
cases
of
scrub
typhus
,
and
14
cases
of
murine
typhus
.
The
seropositive
(
57
.
8
%
,
7
.
7
%
,
and
0
%
,
p
<
0
.
001
)
and
seroconversion
rates
(
50
.
6
%
,
8
.
8
%
,
and
0
%
,
p
<
0
.
001
)
of
M
.
pneumoniae
IgM
,
but
not
M
.
pneumoniae
IgG
and
C
.
pneumoniae
IgG
/
IgM
,
in
acute
Q
fever
were
significantly
higher
than
in
scrub
typhus
and
murine
typhus
.
Another
ELISA
kit
also
revealed
a
high
seropositivity
(
49
.
5
%
)
and
seroconversion
rate
(
33
.
3
%
)
of
M
.
pneumoniae
IgM
in
acute
Q
fever
.
The
temporal
and
age
distributions
of
patients
with
positive
M
.
pneumoniae
IgM
were
not
typical
of
M
.
pneumoniae
pneumonia
.
Comparing
acute
Q
fever
patients
who
were
positive
for
M
.
pneumoniae
IgM
(
59
cases
)
with
those
who
were
negative
(
43
cases
)
,
the
demographic
characteristics
and
underlying
diseases
were
not
different
.
In
addition
,
the
clinical
manifestations
associated
with
atypical
pneumonia
,
including
headache
(
71
.
2
%
vs
.
81
.
4
%
,
p
=
0
.
255
)
,
sore
throat
(
8
.
5
%
vs
.
16
.
3
%
,
p
=
0
.
351
)
,
cough
(
35
.
6
%
vs
.
23
.
3
%
,
p
=
0
.
199
)
,
and
chest
x-
ray
suggesting
pneumonia
(
19
.
3
%
vs
.
9
.
5
%
,
p
=
0
.
258
)
,
were
unchanged
between
the
two
groups
.
Clinicians
should
be
aware
of
the
high
seroprevalence
of
M
.
pneumoniae
IgM
in
acute
Q
fever
,
particularly
with
ELISA
kits
,
which
can
lead
to
misdiagnosis
,
overestimations
of
the
prevalence
of
M
.
pneumoniae
pneumonia
,
and
underestimations
of
the
true
prevalence
of
Q
fever
pneumonia
.
Diseases
Validation
Diseases presenting
"fever"
symptom
22q11.2 deletion syndrome
acute rheumatic fever
alexander disease
allergic bronchopulmonary aspergillosis
canavan disease
carcinoma of the gallbladder
child syndrome
congenital toxoplasmosis
cushing syndrome
cystinuria
dracunculiasis
erdheim-chester disease
esophageal adenocarcinoma
esophageal carcinoma
familial mediterranean fever
focal myositis
hodgkin lymphoma, classical
lamellar ichthyosis
legionellosis
locked-in syndrome
malignant atrophic papulosis
neonatal adrenoleukodystrophy
neuralgic amyotrophy
oculocutaneous albinism
papillon-lefèvre syndrome
pyomyositis
pyruvate dehydrogenase deficiency
scrub typhus
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
typhoid
waldenström macroglobulinemia
wolf-hirschhorn syndrome
This symptom has already been validated