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High seroprevalence of Mycoplasma pneumoniae IgM in acute Q fever by enzyme-linked immunosorbent assay (ELISA).
[scrub typhus]
Q
fever
is
serologically
cross-reactive
with
other
intracellular
microorganisms
.
However
,
studies
of
the
serological
status
of
Mycoplasma
pneumoniae
and
Chlamydophila
pneumoniae
during
Q
fever
are
rare
.
We
conducted
a
retrospective
serological
study
of
M
.
pneumoniae
and
C
.
pneumoniae
by
enzyme-linked
immunosorbent
assay
(
ELISA
)
,
a
method
widely
used
in
clinical
practice
,
in
102
cases
of
acute
Q
fever
,
39
cases
of
scrub
typhus
,
and
14
cases
of
murine
typhus
.
The
seropositive
(
57
.
8
%
,
7
.
7
%
,
and
0
%
,
p
<
0
.
001
)
and
seroconversion
rates
(
50
.
6
%
,
8
.
8
%
,
and
0
%
,
p
<
0
.
001
)
of
M
.
pneumoniae
IgM
,
but
not
M
.
pneumoniae
IgG
and
C
.
pneumoniae
IgG
/
IgM
,
in
acute
Q
fever
were
significantly
higher
than
in
scrub
typhus
and
murine
typhus
.
Another
ELISA
kit
also
revealed
a
high
seropositivity
(
49
.
5
%
)
and
seroconversion
rate
(
33
.
3
%
)
of
M
.
pneumoniae
IgM
in
acute
Q
fever
.
The
temporal
and
age
distributions
of
patients
with
positive
M
.
pneumoniae
IgM
were
not
typical
of
M
.
pneumoniae
pneumonia
.
Comparing
acute
Q
fever
patients
who
were
positive
for
M
.
pneumoniae
IgM
(
59
cases
)
with
those
who
were
negative
(
43
cases
)
,
the
demographic
characteristics
and
underlying
diseases
were
not
different
.
In
addition
,
the
clinical
manifestations
associated
with
atypical
pneumonia
,
including
headache
(
71
.
2
%
vs
.
81
.
4
%
,
p
=
0
.
255
)
,
sore
throat
(
8
.
5
%
vs
.
16
.
3
%
,
p
=
0
.
351
)
,
cough
(
35
.
6
%
vs
.
23
.
3
%
,
p
=
0
.
199
)
,
and
chest
x-
ray
suggesting
pneumonia
(
19
.
3
%
vs
.
9
.
5
%
,
p
=
0
.
258
)
,
were
unchanged
between
the
two
groups
.
Clinicians
should
be
aware
of
the
high
seroprevalence
of
M
.
pneumoniae
IgM
in
acute
Q
fever
,
particularly
with
ELISA
kits
,
which
can
lead
to
misdiagnosis
,
overestimations
of
the
prevalence
of
M
.
pneumoniae
pneumonia
,
and
underestimations
of
the
true
prevalence
of
Q
fever
pneumonia
.
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Diseases presenting
"high seroprevalence"
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