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Scrub typhus meningitis or meningoencephalitis.
[scrub typhus]
Orientia
tsutsugamushi
induces
vasculitis
leading
to
symptoms
of
systemic
organ
invasion
including
meningitis
and
meningoencephalitis
.
We
conducted
a
retrospective
case-control
study
of
scrub
typhus
patients
to
investigate
the
clinical
and
laboratory
features
of
patients
with
scrub
typhus
meningitis
or
meningoencephalitis
,
and
the
therapeutic
outcomes
,
and
to
determine
the
predictor
factors
.
Cases
were
22
patients
with
scrub
typhus
meningitis
or
meningoencephalitis
,
and
controls
were
303
patients
without
meningitis
or
meningoencephalitis
.
Multivariate
analysis
showed
that
the
presence
of
pneumonitis
was
associated
with
the
occurrence
of
scrub
typhus
meningitis
and
meningoencephalitis
(
odds
ratio
[
OR
]
8
.
9
;
P
<
0
.
001
;
confidence
interval
[
CI
]
2
.
9
-
27
.
2
)
.
Although
appropriate
antimicrobials
such
as
doxycycline
agents
were
administered
at
an
early
stage
,
meningitis
or
meningoencephalitis
still
occurred
in
some
cases
.
Physicians
should
be
aware
that
meningitis
or
meningoencephalitis
may
develop
during
appropriate
drug
therapy
such
as
doxycycline
.
Close
observation
and
great
care
are
essential
for
patients
with
risk
factors
,
particularly
pneumonitis
.
Diseases
Validation
Diseases presenting
"early stage"
symptom
adrenomyeloneuropathy
allergic bronchopulmonary aspergillosis
aromatase deficiency
cadasil
carcinoma of the gallbladder
child syndrome
cholangiocarcinoma
congenital adrenal hyperplasia
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
harlequin ichthyosis
hereditary cerebral hemorrhage with amyloidosis
hodgkin lymphoma, classical
kindler syndrome
lymphangioleiomyomatosis
neonatal adrenoleukodystrophy
pyomyositis
scrub typhus
sneddon syndrome
typhoid
von hippel-lindau disease
zellweger syndrome
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