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Estimating the burden of Japanese encephalitis virus and other encephalitides in countries of the mekong region.
[scrub typhus]
Diverse
aetiologies
of
viral
and
bacterial
encephalitis
are
widely
recognized
as
significant
yet
neglected
public
health
issues
in
the
Mekong
region
.
A
robust
analysis
of
the
corresponding
health
burden
is
lacking
.
We
retrieved
75
articles
on
encephalitis
in
the
region
published
in
English
or
in
French
from
1965
through
2011
.
Review
of
available
data
demonstrated
that
they
are
sparse
and
often
derived
from
hospital-based
studies
with
significant
recruitment
bias
.
Almost
half
(
35
of
75
)
of
articles
were
on
Japanese
encephalitis
virus
(
JEV
)
alone
or
associated
with
dengue
.
In
the
Western
Pacific
region
the
WHO
reported
30
,
000
-
50
,
000
annual
JEV
cases
(
15
,
000
deaths
)
between
1966
and
1996
and
4
,
633
cases
(
200
deaths
)
in
2008
,
a
decline
likely
related
to
the
introduction
of
JEV
vaccination
in
China
,
Vietnam
,
or
Thailand
since
the
1980
s
.
Data
on
dengue
,
scrub
typhus
and
rabies
encephalitis
,
among
other
aetiologies
,
are
also
reviewed
and
discussed
.
Countries
of
the
Mekong
region
are
undergoing
profound
demographic
,
economic
and
ecological
change
.
As
the
epidemiological
aspects
of
Japanese
encephalitis
(
JE
)
are
transformed
by
vaccination
in
some
countries
,
highly
integrated
expert
collaborative
research
and
objective
data
are
needed
to
identify
and
prioritize
the
human
health
,
animal
health
and
economic
burden
due
to
JE
and
other
pathogens
associated
with
encephalitides
.
Diseases
Validation
Diseases presenting
"neglected public health issues in the mekong region"
symptom
scrub typhus
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