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Scrub typhus in Punjab: an acute febrile illness with multisystem involvement.
[scrub typhus]
Scrub
typhus
is
an
important
cause
of
acute
febrile
illness
.
This
observational
study
describes
the
clinical
features
and
complications
of
the
patients
diagnosed
to
have
scrub
typhus
in
Christian
Medical
College
&
Hospital
,
Ludhiana
,
Punjab
,
India
.
The
diagnosis
of
scrub
typhus
was
made
by
using
Bioline
SD
Tsutsugamushi
test
kit
which
detects
IgM
,
IgG
or
IgA
antibodies
to
Orientia
tsutsugamushi
.
Sixty
-
two
patients
of
scrub
typhus
were
seen
during
the
study
period
of
1
year
.
The
mean
age
of
the
study
group
was
39
.
9
years
.
All
the
patients
presented
with
fever
,
and
of
these
31
(
50
%
)
had
non-
specific
symptoms
.
All
others
had
some
complication
,
namely
ARDS
/
ALI
in
18
(
29
%
)
,
neurological
involvement
in
12
(
19
.
4
%
)
,
acute
kidney
injury
(
AKI
)
in
16
(
25
.
8
%
)
,
hypotension
in
eight
(
12
.
9
%
)
,
thrombocytopenia
in
23
(
37
.
1
%
)
,
hepatitis
in
34
(
54
.
8
%
)
and
MODS
in
19
(
30
.
7
%
)
.
Eschar
was
present
only
in
nine
patients
.
Three
patients
expired
due
to
multi-organ
failure
,
hypotension
and
metabolic
acidosis
.
Diseases
Validation
Diseases presenting
"fever"
symptom
22q11.2 deletion syndrome
acute rheumatic fever
alexander disease
allergic bronchopulmonary aspergillosis
canavan disease
carcinoma of the gallbladder
child syndrome
congenital toxoplasmosis
cushing syndrome
cystinuria
dracunculiasis
erdheim-chester disease
esophageal adenocarcinoma
esophageal carcinoma
familial mediterranean fever
focal myositis
hodgkin lymphoma, classical
lamellar ichthyosis
legionellosis
locked-in syndrome
malignant atrophic papulosis
neonatal adrenoleukodystrophy
neuralgic amyotrophy
oculocutaneous albinism
papillon-lefèvre syndrome
pyomyositis
pyruvate dehydrogenase deficiency
scrub typhus
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
typhoid
waldenström macroglobulinemia
wolf-hirschhorn syndrome
This symptom has already been validated