Rare Diseases Symptoms Automatic Extraction
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Co-circulation of multiple hemorrhagic fever diseases with distinct clinical characteristics in Dandong, China.
[scrub typhus]
Hemorrhagic
fevers
(
HF
)
caused
by
viruses
and
bacteria
are
a
major
public
health
problem
in
China
and
characterized
by
variable
clinical
manifestations
,
such
that
it
is
often
difficult
to
achieve
accurate
diagnosis
and
treatment
.
The
causes
of
HF
in
85
patients
admitted
to
Dandong
hospital
,
China
,
between
2011
-
2012
were
determined
by
serological
and
PCR
tests
.
Of
these
,
34
patients
were
diagnosed
with
Huaiyangshan
hemorrhagic
fever
(
HYSHF
)
,
34
with
Hemorrhagic
Fever
with
Renal
Syndrome
(
HFRS
)
,
one
with
murine
typhus
,
and
one
with
scrub
typhus
.
Etiologic
agents
could
not
be
determined
in
the
15
remaining
patients
.
Phylogenetic
analyses
of
recovered
bacterial
and
viral
sequences
revealed
that
the
causative
infectious
agents
were
closely
related
to
those
described
in
other
geographical
regions
.
As
these
diseases
have
no
distinctive
clinical
features
in
their
early
stage
,
only
13
patients
were
initially
accurately
diagnosed
.
The
distinctive
clinical
features
of
HFRS
and
HYSHF
developed
during
disease
progression
.
Enlarged
lymph
nodes
,
cough
,
sputum
,
and
diarrhea
were
more
common
in
HYSHF
patients
,
while
more
HFRS
cases
presented
with
headache
,
sore
throat
,
oliguria
,
percussion
pain
kidney
area
,
and
petechiae
.
Additionally
,
HYSHF
patients
displayed
significantly
lower
levels
of
white
blood
cells
(
WBC
)
,
higher
levels
of
creations
kinase
(
CK
)
and
alanine
aminotransferase
(
ALT
)
,
while
HFRS
patients
presented
with
an
elevation
of
blood
urea
nitrogen
(
BUN
)
and
creatinine
(
CREA
)
.
These
clinical
features
will
assist
in
the
accurate
diagnosis
of
both
HYSHF
and
HFRS
.
Overall
,
our
data
reveal
the
complexity
of
pathogens
causing
HFs
in
a
single
Chinese
hospital
,
and
highlight
the
need
for
accurate
early
diagnosis
and
a
better
understanding
of
their
distinctive
clinical
features
.
Diseases
Validation
Diseases presenting
"petechiae"
symptom
erythropoietic protoporphyria
scrub typhus
This symptom has already been validated