Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Co-circulation of multiple hemorrhagic fever diseases with distinct clinical characteristics in Dandong, China.
[scrub typhus]
Hemorrhagic
fevers
(
HF
)
caused
by
viruses
and
bacteria
are
a
major
public
health
problem
in
China
and
characterized
by
variable
clinical
manifestations
,
such
that
it
is
often
difficult
to
achieve
accurate
diagnosis
and
treatment
.
The
causes
of
HF
in
85
patients
admitted
to
Dandong
hospital
,
China
,
between
2011
-
2012
were
determined
by
serological
and
PCR
tests
.
Of
these
,
34
patients
were
diagnosed
with
Huaiyangshan
hemorrhagic
fever
(
HYSHF
)
,
34
with
Hemorrhagic
Fever
with
Renal
Syndrome
(
HFRS
)
,
one
with
murine
typhus
,
and
one
with
scrub
typhus
.
Etiologic
agents
could
not
be
determined
in
the
15
remaining
patients
.
Phylogenetic
analyses
of
recovered
bacterial
and
viral
sequences
revealed
that
the
causative
infectious
agents
were
closely
related
to
those
described
in
other
geographical
regions
.
As
these
diseases
have
no
distinctive
clinical
features
in
their
early
stage
,
only
13
patients
were
initially
accurately
diagnosed
.
The
distinctive
clinical
features
of
HFRS
and
HYSHF
developed
during
disease
progression
.
Enlarged
lymph
nodes
,
cough
,
sputum
,
and
diarrhea
were
more
common
in
HYSHF
patients
,
while
more
HFRS
cases
presented
with
headache
,
sore
throat
,
oliguria
,
percussion
pain
kidney
area
,
and
petechiae
.
Additionally
,
HYSHF
patients
displayed
significantly
lower
levels
of
white
blood
cells
(
WBC
)
,
higher
levels
of
creations
kinase
(
CK
)
and
alanine
aminotransferase
(
ALT
)
,
while
HFRS
patients
presented
with
an
elevation
of
blood
urea
nitrogen
(
BUN
)
and
creatinine
(
CREA
)
.
These
clinical
features
will
assist
in
the
accurate
diagnosis
of
both
HYSHF
and
HFRS
.
Overall
,
our
data
reveal
the
complexity
of
pathogens
causing
HFs
in
a
single
Chinese
hospital
,
and
highlight
the
need
for
accurate
early
diagnosis
and
a
better
understanding
of
their
distinctive
clinical
features
.
Diseases
Validation
Diseases presenting
"enlarged lymph nodes"
symptom
esophageal adenocarcinoma
esophageal squamous cell carcinoma
hodgkin lymphoma, classical
lymphangioleiomyomatosis
scrub typhus
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom