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Association between heat shock protein 70 gene polymorphisms and clinical outcomes in intensive care unit patients with sepsis.
[scrub typhus]
The
objective
of
the
following
study
is
to
evaluate
the
associations
between
single
nucleotide
polymorphisms
(
SNPs
)
in
the
Heat
Shock
Protein
70
(
HSP
70
)
gene
,
gene
expression
of
interleukin-
6
(
IL
-
6
)
and
tumor
necrosis
factor
-alpha
(
TNF
-α
)
and
medical
intensive
care
unit
(
MICU
)
stay
and
organ
failure
in
sepsis
.
MICU
patients
with
sepsis
were
genotyped
for
rs
1061581
,
rs
2227956
,
rs
1008438
and
rs
1043618
polymorphisms
in
HSP
70
gene
using
polymerase
chain
reaction
(
PCR
)
-
restriction
fragment
length
polymorphism
analysis
or
allele-
specific
PCR
.
Messenger
ribonucleic
acid
(
mRNA
)
expression
of
IL
-
6
and
TNF
-α
were
quantitated
in
peripheral
blood
lymphocytes
.
Outcomes
were
recorded
.
108
patients
(
48
male
)
aged
40
.
7
±
16
.
0
(
mean
±
standard
deviation
)
years
included
H
1
N
1
infection
(
36
)
,
scrub
typhus
(
29
)
and
urosepsis
(
12
)
.
Seventy
-
one
(
65
.
7
%
)
had
dysfunction
of
three
or
more
organ
systems
,
66
patients
(
61
.
1
%
)
were
treated
by
mechanical
ventilation
,
21
(
19
.
4
%
)
needed
dialysis
.
ICU
stay
was
9
.
3
±
7
.
3
days
.
Mortality
was
38
.
9
%
.
One
or
more
SNPs
were
noted
in
101
/
108
(
93
.
5
%
)
and
organ
failure
was
noted
in
only
1
/
7
patients
without
a
single
SNP
.
The
A
allelotypes
of
rs
1061581
and
rs
1008438
were
associated
with
hematological
dysfunction
(
P
=
0
.
03
and
0
.
07
)
and
longer
ICU
stay
(
P
=
0
.
05
and
0
.
04
)
,
whereas
IL
-
6
and
TNF
-α
mRNA
levels
were
associated
with
central
nervous
system
dysfunction
.
HSP
70
genotypes
may
determine
some
adverse
outcomes
in
patients
with
sepsis
.
Diseases
Validation
Diseases presenting
"central nervous system dysfunction"
symptom
adrenomyeloneuropathy
pyruvate dehydrogenase deficiency
scrub typhus
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