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A random Abstract
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A hematogenously disseminated Orientia tsutsugamsushi-infected murine model of scrub typhus.
[scrub typhus]
Orientia
tsutsugamushi
,
the
etiologic
agent
of
scrub
typhus
,
is
a
mite-borne
rickettsia
transmitted
by
the
parasitic
larval
stage
of
trombiculid
mites
.
Approximately
one
-
third
of
the
world
's
population
is
at
risk
of
infection
with
Orientia
tsutsugamushi
,
emphasizing
its
importance
in
global
health
.
In
order
to
study
scrub
typhus
,
Orientia
tsutsugamushi
Karp
strain
has
been
used
extensively
in
mouse
studies
with
various
inoculation
strategies
and
little
success
in
inducing
disease
progression
similar
to
that
of
human
scrub
typhus
.
The
objective
of
this
project
was
to
develop
a
disease
model
with
pathology
and
target
cells
similar
to
those
of
severe
human
scrub
typhus
.
This
study
reports
an
intravenous
infection
model
of
scrub
typhus
in
C
5
7
BL
/
6
mice
.
This
mouse
strain
was
susceptible
to
intravenous
challenge
,
and
lethal
infection
occurred
after
intravenous
inoculation
of
1
.
25
×
10
(
6
)
focus
(
FFU
)
forming
units
.
Signs
of
illness
in
lethally
infected
mice
appeared
on
day
6
with
death
occurring
∼
6
days
later
.
Immunohistochemical
staining
for
Orientia
antigens
demonstrated
extensive
endothelial
infection
,
most
notably
in
the
lungs
and
brain
.
Histopathological
analysis
revealed
cerebral
perivascular
,
lymphohistiocytic
infiltrates
,
focal
hemorrhages
,
meningoencephalitis
,
and
interstitial
pneumonia
.
Disseminated
infection
of
endothelial
cells
with
Orientia
in
C
5
7
BL
/
6
mice
resulted
in
pathology
resembling
that
of
human
scrub
typhus
.
The
use
of
this
model
will
allow
detailed
characterization
of
the
mechanisms
of
immunity
to
and
pathogenesis
of
O
.
tsutsugamushi
infection
.
Diseases
Validation
Diseases presenting
"pneumonia"
symptom
22q11.2 deletion syndrome
acute rheumatic fever
allergic bronchopulmonary aspergillosis
alpha-thalassemia
classical phenylketonuria
cohen syndrome
congenital diaphragmatic hernia
heparin-induced thrombocytopenia
hydrocephalus with stenosis of the aqueduct of sylvius
junctional epidermolysis bullosa
lamellar ichthyosis
legionellosis
liposarcoma
lymphangioleiomyomatosis
monosomy 21
oculocutaneous albinism
omenn syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
scrub typhus
severe combined immunodeficiency
triple a syndrome
waldenström macroglobulinemia
wiskott-aldrich syndrome
x-linked adrenoleukodystrophy
zellweger syndrome
This symptom has already been validated
