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Clinical profile of scrub typhus in children and its association with hemophagocytic lymphohistiocytosis.
[scrub typhus]
To
study
the
clinical
profile
of
children
with
scrub
typhus
and
its
association
with
hemophagocytic
lymphohistiocytosis
.
Children
presenting
with
unexplained
fever
and
multi-systemic
involvement
between
May
to
December
2011
were
tested
for
scrub
typhus
using
IgM
ELISA
kits
.
Occurrence
of
Hemophagocytic
lymphohistiocytosis
in
IgM
positive
cases
of
scrub
typhus
was
studied
.
Of
the
35
children
with
unexplained
fever
and
multi-systemic
involvement
,
15
children
(
9
boys
)
tested
positive
for
scrub
typhus
.
Thrombocytopenia
,
hypoalbuminemia
and
raised
hepatic
transaminases
were
observed
in
all
children
.
Out
of
seven
children
evaluated
for
hemophagocytic
lymphohistiocytosis
.
3
met
the
criteria
for
hemophagocytosis
.
Two
children
(
one
with
hemophagocytic
lymphohistiocytosis
)
died
.
Scrub
typhus
is
a
common
cause
of
unexplained
fever
in
children
in
northern
India
.
Hemophagocytic
lymphohistiocytosis
can
occasionally
complicate
scrub
typhus
in
children
.
Diseases
Validation
Diseases presenting
"common cause"
symptom
achondroplasia
acute rheumatic fever
adrenomyeloneuropathy
allergic bronchopulmonary aspergillosis
alpha-thalassemia
aniridia
aromatase deficiency
benign recurrent intrahepatic cholestasis
cadasil
child syndrome
coats disease
congenital adrenal hyperplasia
congenital toxoplasmosis
cushing syndrome
erdheim-chester disease
esophageal adenocarcinoma
esophageal squamous cell carcinoma
fabry disease
familial hypocalciuric hypercalcemia
hydrocephalus with stenosis of the aqueduct of sylvius
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
lamellar ichthyosis
legionellosis
liposarcoma
locked-in syndrome
malignant atrophic papulosis
neonatal adrenoleukodystrophy
neuralgic amyotrophy
pendred syndrome
primary hyperoxaluria type 1
pyruvate dehydrogenase deficiency
scrub typhus
systemic capillary leak syndrome
thoracic outlet syndrome
typhoid
von hippel-lindau disease
wiskott-aldrich syndrome
zellweger syndrome
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