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Clinical profile of scrub typhus in children and its association with hemophagocytic lymphohistiocytosis.
[scrub typhus]
To
study
the
clinical
profile
of
children
with
scrub
typhus
and
its
association
with
hemophagocytic
lymphohistiocytosis
.
Children
presenting
with
unexplained
fever
and
multi-systemic
involvement
between
May
to
December
2011
were
tested
for
scrub
typhus
using
IgM
ELISA
kits
.
Occurrence
of
Hemophagocytic
lymphohistiocytosis
in
IgM
positive
cases
of
scrub
typhus
was
studied
.
Of
the
35
children
with
unexplained
fever
and
multi-systemic
involvement
,
15
children
(
9
boys
)
tested
positive
for
scrub
typhus
.
Thrombocytopenia
,
hypoalbuminemia
and
raised
hepatic
transaminases
were
observed
in
all
children
.
Out
of
seven
children
evaluated
for
hemophagocytic
lymphohistiocytosis
.
3
met
the
criteria
for
hemophagocytosis
.
Two
children
(
one
with
hemophagocytic
lymphohistiocytosis
)
died
.
Scrub
typhus
is
a
common
cause
of
unexplained
fever
in
children
in
northern
India
.
Hemophagocytic
lymphohistiocytosis
can
occasionally
complicate
scrub
typhus
in
children
.