Rare Diseases Symptoms Automatic Extraction
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The intracellular pathogen Orientia tsutsugamushi responsible for scrub typhus induces lipid droplet formation in mouse fibroblasts.
[scrub typhus]
Mammalian
cells
store
excess
fatty
acids
in
the
form
of
triglycerides
within
lipid
droplets
.
The
intracellular
bacterium
Orientia
tsutsugamush
is
the
causative
agent
of
severe
human
rickettiosis
.
We
found
that
O
.
tsutsugamushi
infection
induces
the
formation
of
lipid
droplets
in
mouse
L-
929
fibroblasts
.
In
infected
cells
,
a
parallel
increase
in
the
number
of
lipid
droplets
and
pathogens
was
observed
.
Interestingly
,
the
pathogen-infection
induced
the
accumulation
of
triglycerides
even
without
external
supply
of
fatty
acids
.
These
results
suggest
that
O
.
tsutsugamushi
alters
lipid
metabolism
of
host
cells
to
induce
lipid
droplets
.