Case report of pyruvate dehydrogenase deficiency with unusual increase of fats during ketogenic diet treatment.

[pyruvate dehydrogenase deficiency]

This article describes a case of pyruvate dehydrogenase deficiency in a 3 -year -old boy who presented generalized hypotonia , severe psychomotor development delay , and generalized and partial seizures and was refractory to antiepileptic drugs . After the diagnosis , the patient was put on a ketogenic diet . Six months later , seizure frequency was reduced and psychomotor development had improved . At the same time he presented some side effects , such as 2 episodes of significant increases in cholesterol and triglycerides associated with viral respiratory infections . The latter decreased with a supplementation of ω-3 fatty acids and an increase in caloric intake .