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Ketogenic diet: an early option for epilepsy treatment, instead of a last choice only.
[pyruvate dehydrogenase deficiency]
Ketogenic
diet
(
KD
)
was
usually
tried
as
a
last
resort
in
the
treatment
of
intractable
epilepsy
after
failure
of
many
antiepileptics
and
even
epilepsy
surgery
.
Glucose
transporter-
1
deficiency
and
pyruvate
dehydrogenase
deficiency
must
be
treated
with
KD
as
the
first
choice
because
of
inborn
errors
of
glucose
metabolism
.
Infantile
spasms
,
tuberous
sclerosis
complex
,
Rett
syndrome
,
Doose
syndrome
,
Dravet
syndrome
,
etc
.
,
appear
to
respond
to
KD
,
and
it
has
been
suggested
by
the
international
consensus
statement
to
use
KD
early
.
We
believe
that
all
patients
with
epilepsy
,
except
those
with
contraindicated
situations
such
as
pyruvate
carboxylase
deficiency
,
porphyria
,
β-oxidation
defects
,
primary
carnitine
deficiency
,
etc
.
,
may
try
KD
before
trying
other
regimens
.
Diseases
Validation
Diseases presenting
"carnitine deficiency"
symptom
homocystinuria without methylmalonic aciduria
pyruvate dehydrogenase deficiency
x-linked adrenoleukodystrophy
This symptom has already been validated