Variability of antibiotic susceptibility and toxin production of Staphylococcus aureus strains isolated from skin, soft tissue, and bone related infections.

[pyomyositis]

Staphylococcus aureus is an opportunistic commensal bacterium that mostly colonizes the skin and soft tissues . The pathogenicity of S . aureus is due to both its ability to resist antibiotics , and the production of toxins . Here , we characterize a group of genes responsible for toxin production and antibiotic resistance of S . aureus strains isolated from skin , soft tissue , and bone related infections .A total of 136 S . aureus strains were collected from five different types of infection : furuncles , pyomyositis , abscesses , Buruli ulcers , and osteomyelitis , from hospital admissions and out-patients in Benin . All strains were resistant to benzyl penicillin , while 25 % were resistant to methicillin , and all showed sensitivity to vancomycin . Panton -Valentine leukocidin (PVL ) was the most commonly produced virulence factor (70 %), followed by staphylococcal enterotoxin B (44 %). Exfoliative toxin B was produced by 1 .3 % of the strains , and was only found in isolates from Buruli ulcers . The tsst-1 , sec , and seh genes were rarely detected (â‰¤1 %).This study provides new insight into the prevalence of toxin and antibiotic resistance genes in S . aureus strains responsible for skin , soft tissue , and bone infections . Our results showed that PVL was strongly associated with pyomyositis and osteomyelitis , and that there is a high prevalence of PVL-MRSA skin infections in Benin .

Diseases
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Diseases presenting "produced virulence factor (70%" symptom

pyomyositis

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