Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi (CLOVE) syndrome: CNS malformations and seizures may be a component of this disorder.

[proteus syndrome]

A newborn girl was found to have a massive lymphatic truncal vascular malformation with overlying cutaneous venous anomaly associated with overgrown feet and splayed toes . These manifestations comprise the recently described CLOVE syndrome . She also had cranial asymmetry and developed generalized seizures , which were treated with anticonvulsants . Cranial CT showed encephalomalacia , widening of the ventricles and the sulci , hemimegalencephaly (predominantly white matter ) and partial agenesis of corpus callosum . Review of the literature identified several other patients with CLOVE syndrome , some of whom were misdiagnosed as having Proteus syndrome , with strikingly similar manifestations . We conclude that CNS manifestations including hemimegalencephaly , dysgenesis of the corpus callosum , neuronal migration defects , and the consequent seizures , may be an rarely recognized manifestation of CLOVE syndrome .

Diseases
Validation

Diseases presenting "cranial asymmetry" symptom

proteus syndrome

This symptom has already been validated