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Our Project
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Combination of microstereolithography and electrospinning to produce membranes equipped with niches for corneal regeneration.
[aniridia]
Corneal
problems
affect
millions
of
people
worldwide
reducing
their
quality
of
life
significantly
.
Corneal
disease
can
be
caused
by
illnesses
such
as
Aniridia
or
Steven
Johnson
Syndrome
as
well
as
by
external
factors
such
as
chemical
burns
or
radiation
.
Current
treatments
are
(
i
)
the
use
of
corneal
grafts
and
(
ii
)
the
use
of
stem
cell
expanded
in
the
laboratory
and
delivered
on
carriers
(
e
.
g
.
,
amniotic
membrane
)
;
these
treatments
are
relatively
successful
but
unfortunately
they
can
fail
after
3
-
5
years
.
There
is
a
need
to
design
and
manufacture
new
corneal
biomaterial
devices
able
to
mimic
in
detail
the
physiological
environment
where
stem
cells
reside
in
the
cornea
.
Limbal
stem
cells
are
located
in
the
limbus
(
circular
area
between
cornea
and
sclera
)
in
specific
niches
known
as
the
Palisades
of
Vogt
.
In
this
work
we
have
developed
a
new
platform
technology
which
combines
two
cutting-edge
manufacturing
techniques
(
microstereolithography
and
electrospinning
)
for
the
fabrication
of
corneal
membranes
that
mimic
to
a
certain
extent
the
limbus
.
Our
membranes
contain
artificial
micropockets
which
aim
to
provide
cells
with
protection
as
the
Palisades
of
Vogt
do
in
the
eye
.
Diseases
Validation
Diseases presenting
"steven johnson syndrome as well as by external factors such as chemical burns or radiation"
symptom
aniridia
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