Proteus syndrome: three case reports with a review of the literature.

[proteus syndrome]

Proteus syndrome (PS ) is a rare , progressive disorder that manifests as asymmetric , disproportionate overgrowth affecting tissues derived from any germline layer . Cases of PS from 2005 -2010 were retrieved from the pathology files at our institution . Two confirmed cases and one possible case of PS were identified . All patients came from different ethnic backgrounds . Patient 1 displayed classic skin and overgrowth lesions . Patient 2 displayed various features , particularly vascular malformations . Patient 3 demonstrated a cerebriform connective tissue nevus alone . These patients demonstrate the spectrum of presentations of PS . Much is left to learn about this disfiguring disease .