Overgrowth syndromes.

[proteus syndrome]

Human growth ensues from a complex interplay of physiological factors , in the wider setting of varying genetic traits and environmental influences . Intensive research in these divergent areas , and particularly in the field of genetics , continues to clarify the molecular basis of disorders which result in overgrowth , and it is therefore timely to provide a review of these findings .This article provides an overview of the factors which regulate growth , followed by a discussion of the more commonly encountered overgrowth syndromes and their genetic basis as it is understood at the current time . There is also an added focus on recently discovered genetic associations in some conditions , such as Weaver , Perlman and Proteus syndromes .New discoveries continue to be made regarding the genetic basis for many overgrowth syndromes and the development of a much needed molecular classification system for overgrowth may become possible as the interlinking functions of these genes on growth are unravelled . As there exists a wide spectrum of syndromes , disorders resulting in overgrowth can represent a diagnostic and therapeutic challenge , from those causing prenatal overgrowth with a poor prognosis to less severe genetic aberrations which are identified in later childhood or adult life .

Diseases
Validation

Diseases presenting "adult life" symptom

proteus syndrome

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