Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Disease recurrence in paediatric renal transplantation.
[primary hyperoxaluria type 1]
Renal
transplantation
(
Tx
)
is
the
treatment
of
choice
for
end-
stage
renal
disease
.
The
incidence
of
acute
rejection
after
renal
Tx
has
decreased
because
of
improving
early
immunosuppression
,
but
the
risk
of
disease
recurrence
(
DR
)
is
becoming
relatively
high
,
with
a
greater
prevalence
in
children
than
in
adults
,
thereby
increasing
patient
morbidity
,
graft
loss
(
GL
)
and
,
sometimes
,
mortality
rate
.
The
current
overall
graft
loss
to
DR
is
7
-
8
%
,
mainly
due
to
primary
glomerulonephritis
(
70
-
80
%
)
and
inherited
metabolic
diseases
.
The
more
typical
presentation
is
a
recurrence
of
the
full
disease
,
either
with
a
high
risk
of
GL
(
focal
and
segmental
glomerulosclerosis
14
-
50
%
DR
,
40
-
60
%
GL
;
atypical
haemolytic
uraemic
syndrome
20
-
80
%
DR
,
10
-
83
%
GL
;
membranoproliferative
glomerulonephritis
30
-
100
%
DR
,
17
-
61
%
GL
;
membranous
nephropathy
approximately
30
%
DR
,
approximately
50
%
GL
;
lipoprotein
glomerulopathy
approximately
100
%
DR
and
GL
;
primary
hyperoxaluria
type
1
80
-
100
%
DR
and
GL
)
or
with
a
low
risk
of
GL
[
immunoglobulin
(
Ig
)
A
nephropathy
36
-
60
%
DR
,
7
-
10
%
GL
;
systemic
lupus
erythematosus
0
-
30
%
DR
,
0
-
5
%
GL
;
anti-neutrophilic
cytoplasmic
antibody
(
ANCA
)
-
associated
glomerulonephritis
]
.
Recurrence
may
also
occur
with
a
delayed
risk
of
GL
,
such
as
insulin-dependent
diabetes
mellitus
,
sickle
cell
disease
,
endemic
nephropathy
,
and
sarcoidosis
.
In
other
primary
diseases
,
the
post-
Tx
course
may
be
complicated
by
specific
events
that
are
different
from
overt
recurrence
:
proteinuria
or
cancer
in
some
genetic
forms
of
nephrotic
syndrome
,
anti-glomerular
basement
membrane
antibodies-associated
glomerulonephritis
(
Alport
syndrome
,
Goodpasture
syndrome
)
,
and
graft
involvement
as
a
consequence
of
lower
urinary
tract
abnormality
or
human
immunodeficiency
virus
(
HIV
)
nephropathy
.
Some
other
post-
Tx
conditions
may
mimic
recurrence
,
such
as
de
novo
membranous
glomerulonephritis
,
IgA
nephropathy
,
microangiopathy
,
or
isolated
specific
deposits
(
cystinosis
,
Fabry
disease
)
.
Adequate
strategies
should
therefore
be
added
to
kidney
Tx
,
such
as
donor
selection
,
associated
liver
Tx
,
plasmatherapy
,
specific
immunosuppression
protocols
.
In
such
conditions
,
very
few
patients
may
be
excluded
from
kidney
Tx
only
because
of
a
major
risk
of
DR
and
repeated
GL
.
In
the
near
future
the
issue
of
DR
after
kidney
Tx
may
benefit
from
alternatives
to
organ
Tx
,
such
as
recombinant
proteins
,
specific
monoclonal
antibodies
,
cell
/
gene
therapy
,
and
chaperone
molecules
.
Diseases
Validation
Diseases presenting
"current overall graft loss"
symptom
primary hyperoxaluria type 1
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom