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Bone metabolism in oxalosis: a single-center study using new imaging techniques and biomarkers.
[primary hyperoxaluria type 1]
The
deposition
of
calcium
oxalate
crystals
in
the
kidney
and
bone
is
a
hallmark
of
primary
hyperoxaluria
type
1
(
PH
1
)
.
We
report
here
an
evaluation
of
the
bone
status
of
12
PH
1
children
based
on
bone
biomarkers
[
parathyroid
hormone
,
vitamin
D
,
fibroblast
growth
factor
23
(
FGF
23
)
]
and
radiological
assessments
(
skeletal
age
,
three
-dimensional
high
-resolution
peripheral
quantitative
computed
tomography
,
HR
-pQCT
)
carried
out
within
the
framework
of
a
cross-sectional
single
-center
study
.
The
controls
consisted
of
healthy
and
children
with
chronic
kidney
disease
already
enrolled
in
local
bone
and
mineral
metabolism
studies
.
The
mean
age
(
+
or
-
standard
deviation
)
age
of
the
patients
was
99
(
+
or
-
63
)
months
.
Six
children
suffered
from
fracture
.
Bone
maturation
was
accelerated
in
five
patients
,
four
of
whom
were
<
5
years
.
The
combination
of
new
imaging
techniques
and
biomarkers
highlighted
new
and
unexplained
features
of
PH
1
:
advanced
skeletal
age
in
young
PH
1
patients
,
increased
FGF
23
levels
and
decreased
total
volumetric
bone
mineral
density
with
bone
microarchitecture
alteration
.
Diseases
Validation
Diseases presenting
"bone microarchitecture alteration"
symptom
primary hyperoxaluria type 1
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