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Liver transplantation in oxalosis prior to advanced chronic kidney disease.
[primary hyperoxaluria type 1]
While
curative
of
the
disease
,
combined
kidney
and
liver
transplantation
(
K
/
LTx
)
for
primary
hyperoxaluria
type
1
(
PH
1
)
continues
to
carry
with
it
a
risk
for
patient
death
of
15
-
25
%
,
which
over
time
may
not
differ
from
that
of
kidney
transplantation
alone
(
KTx
)
.
In
this
editorial
,
survival
data
are
reviewed
as
well
as
the
limited
data
available
for
kidney
graft
function
,
which
may
favor
K
/
LTx
in
the
short
term
but
is
more
uncertain
in
the
longer
term
.
The
window
of
opportunity
that
favors
preemptive
K
/
LTx
is
relatively
narrow
and
is
likely
even
narrower
for
preemptive
isolated
LTx
.
Capability
and
experience
in
the
medical
management
of
such
patients
,
and
the
opportunities
available
,
as
well
as
likely
patient
compliance
,
so
far
without
supporting
data
,
may
be
the
most
important
determination
of
the
best
strategy
for
management
.
Diseases
Validation
Diseases presenting
"short term"
symptom
primary hyperoxaluria type 1
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