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Hemoglobin Constant Spring is markedly high in women of an ethnic minority group in Vietnam: a community-based survey and hematologic features.
[alpha-thalassemia]
A
community-based
survey
was
conducted
to
determine
the
prevalence
and
gene
frequency
of
Hemoglobin
Constant
Spring
(
Hb
CS
)
and
other
forms
of
thalassemia
among
an
ethnic
minority
in
Vietnam
.
A
total
of
298
ethnic
minority
women
,
the
C
ó-
Tu
,
participated
.
Hematological
parameters
and
hemoglobin
profiles
were
analyzed
using
standard
automated
analyzers
.
Alpha
-
and
beta-thalassemia
mutations
were
identified
using
polymerase
chain
reaction
(
PCR
)
based
technology
.
Of
the
298
women
,
141
(
47
.
3
%
)
carried
thalassemia
genes
.
Hemoglobin
Constant
Spring
(
Hb
CS
)
is
the
most
common
with
a
markedly
high
frequency
of
0
.
143
(
overall
prevalence
=
26
.
2
%
)
.
The
heterozygous
state
of
Hb
CS
was
found
in
one
-
fifth
(
20
.
5
%
)
of
women
participating
.
Seven
women
(
2
.
4
%
)
were
Hb
CS
homozygote
.
The
overall
prevalence
for
Hb
E
was
13
.
8
%
,
and
10
.
7
%
for
α
(
+
)
-
thalassemia
.
Other
forms
of
thalassemia
included
0
.
67
%
β-thalassemia
,
and
0
.
34
%
Hb
Paksé
.
None
of
the
participants
had
the
α
(
0
)
-
thalassemia
gene
.
The
study
provides
basic
epidemiological
information
about
Hb
CS
as
well
as
other
forms
of
thalassemia
for
a
specific
group
of
an
ethnic
minority
in
Vietnam
.
The
data
will
be
useful
for
further
study
on
the
distribution
of
thalassemia
in
Southeast
Asia
.
Diseases
Validation
Diseases presenting
"markedly high frequency"
symptom
alpha-thalassemia
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