Sequential liver and kidney transplantation from a single living donor in two young adults with primary hyperoxaluria type 1.

[primary hyperoxaluria type 1]

Using living donor organs for sequential liver and kidney transplantation (SeqLKT ) in patients with primary hyperoxaluria type 1 (PH 1 ) has emerged as a viable approach . Taking both organs from a single donor , however , is rare . There are 8 reported cases of SeqLKT in the literature , and in all but 1 case , children were the recipients . We present our experience with SeqLKT in 2 young adults with PH 1 . In the first case , with an interval between procedures of 4 .5 months , SeqLKT was performed with a right liver lobe from a 47 -year -old father for his 19 -year -old son with PH 1 who was on dialysis for 2 years before transplantation . Both the donor and the recipient had an uneventful recovery , although there was re -exploration for the control of bleeding in the recipient after liver transplantation . Thirty -three months after transplantation , the patient had normal liver and renal function . In the second case , with an interval between procedures of 22 days , SeqLKT was performed with organs from a 45 -year -old father for his 19 -year -old daughter with PH 1 who was on dialysis for 8 months . The recipient procedures , including right liver lobe transplantation and kidney transplantation , were uneventful . The donor underwent percutaneous drainage of a subphrenic collection and subsequently fully recovered . Eighteen months after transplantation , the recipient 's liver and renal allograft function was normal . In conclusion , because of the severe organ shortage , living related SeqLKT using the same donor should be carefully considered for young adults with PH 1 .

Diseases
Validation

Diseases presenting "liver transplantation" symptom

allergic bronchopulmonary aspergillosis

benign recurrent intrahepatic cholestasis

carcinoma of the gallbladder

cholangiocarcinoma

cystinuria

erythropoietic protoporphyria

heparin-induced thrombocytopenia

locked-in syndrome

megacystis-microcolon-intestinal hypoperistalsis syndrome

primary hyperoxaluria type 1

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