Rare Diseases Symptoms Automatic Extraction
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A random Abstract
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Our Team
Nocturnal home hemodialysis for a patient with type 1 hyperoxaluria.
[primary hyperoxaluria type 1]
Type
1
primary
hyperoxaluria
is
a
genetic
disorder
caused
by
deficiency
of
the
liver
-
specific
peroxisomal
enzyme
alanine-glyoxylate
aminotransferase
.
This
enzyme
deficiency
leads
to
excess
oxalate
production
and
deposition
of
calcium
oxalate
salts
,
resulting
in
kidney
failure
and
systemic
oxalosis
.
Aside
from
combined
liver
/
kidney
transplantation
,
no
curative
treatment
exists
.
Various
strategies
for
optimizing
dialysis
treatment
have
been
evaluated
,
but
neither
conventional
hemodialysis
nor
peritoneal
dialysis
can
keep
pace
with
oxalate
production
in
this
patient
population
.
In
this
report
,
we
describe
a
patient
with
end-
stage
renal
disease
from
type
1
primary
hyperoxaluria
managed
with
nocturnal
home
hemodialysis
.
Performing
hemodialysis
8
-
10
hours
each
night
with
blood
flow
of
350
mL
/
min
and
total
dialysate
volume
of
60
L
,
she
has
maintained
pre-
and
postdialysis
serum
oxalate
levels
at
or
below
the
level
of
supersaturation
.
We
also
review
published
literature
regarding
oxalate
removal
in
various
modalities
of
dialysis
in
patients
with
type
1
primary
hyperoxaluria
.
In
our
patient
,
nocturnal
hemodialysis
has
controlled
serum
oxalate
levels
better
than
conventional
hemodialysis
therapies
.
Home
nocturnal
hemodialysis
should
be
considered
an
option
for
management
of
patients
with
end-
stage
renal
disease
from
type
1
hyperoxaluria
who
are
awaiting
transplantation
.