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A random Abstract
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Distinct roles of Kaposi's sarcoma-associated herpesvirus-encoded viral interferon regulatory factors in inflammatory response and cancer.
[primary effusion lymphoma]
Kaposi
's
sarcoma
-associated
herpesvirus
(
KSHV
)
is
the
etiologic
agent
associated
with
Kaposi
's
sarcoma
(
KS
)
,
primary
effusion
lymphoma
(
PEL
)
,
and
multicentric
Castleman
disease
(
MCD
)
.
Similar
to
other
herpesviruses
,
KSHV
has
two
life
cycles
,
latency
and
lytic
replication
.
In
latency
,
the
KSHV
genome
persists
as
a
circular
episome
in
the
nucleus
of
the
host
cell
and
only
a
few
viral
genes
are
expressed
.
In
this
review
,
we
focus
on
oncogenic
,
antiapoptotic
,
and
immunomodulating
properties
of
KSHV-encoded
homologues
of
cellular
interferon
regulatory
factors
(
IRFs
)
-
-
viral
IRF
1
(
vIRF
1
)
to
vIRF
4
-
-
and
their
possible
role
in
the
KSHV-mediated
antiviral
response
,
apoptosis
,
and
oncogenicity
.
Diseases
Validation
Diseases presenting
"lymphoma"
symptom
adrenal incidentaloma
alpha-thalassemia
carcinoma of the gallbladder
cushing syndrome
dedifferentiated liposarcoma
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
familial hypocalciuric hypercalcemia
focal myositis
hirschsprung disease
hodgkin lymphoma, classical
kabuki syndrome
liposarcoma
locked-in syndrome
monosomy 21
oculocutaneous albinism
primary effusion lymphoma
severe combined immunodeficiency
systemic capillary leak syndrome
waldenström macroglobulinemia
wiskott-aldrich syndrome
This symptom has already been validated
