Is valganciclovir really effective in primary effusion lymphoma: case report of an HIV(-) EBV(-) HHV8(+) patient.

[primary effusion lymphoma]

Primary effusion lymphoma (PEL ) is a human herpesvirus 8 (HHV 8 ) associated lymphoproliferative disease characterized by effusions in body cavities , and lack of tumor mass . Valganciclovir is a treatment option in PEL , however , little is known about its clinical efficacy . Ganciclovir has been reported to be effective in HHV 8 (+) multicentric Castleman 's disease (MCD ) by decreasing the plasma HHV 8 load , which is an important factor in the induction and persistence of MCD , Kaposi 's sarcoma (KS ), and PEL . But there is no information about the efficacy of valganciclovir on HHV 8 associated lymphoproliferative diseases . Here , we present the first EBV and HIV negative , HHV 8 positive PEL case treated with valganciclovir ; for whom it initially reduced the viral load leading to a transient partial improvement in the clinical status , but failed to induce a complete and durable remission .

Diseases
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Diseases presenting "persistence of mcd" symptom

primary effusion lymphoma

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