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Our Team
Molecular studies and therapeutic targeting of Kaposi's sarcoma herpesvirus (KSHV/HHV-8) oncogenesis.
[primary effusion lymphoma]
Kaposi
's
sarcoma
herpesvirus
or
human
herpesvirus-
8
(
KSHV
/
HHV-
8
)
is
the
etiological
agent
of
Kaposi
's
sarcoma
(
KS
)
,
an
AIDS-defining
angioproliferative
neoplasm
that
continues
to
be
a
major
global
health
problem
and
,
of
primary
effusion
lymphoma
(
PEL
)
,
a
rare
incurable
B-
cell
lymphoma
.
This
review
describes
the
research
from
our
laboratory
and
its
collaborators
to
uncover
molecular
mechanisms
of
viral
oncogenesis
in
order
to
develop
new
pathogenesis-based
therapies
to
the
KSHV-induced
AIDS
malignancies
KS
and
PEL
.
They
include
the
discovery
of
the
viral
angiogenic
oncogene
G
protein-coupled
receptor
Â
(
vGPCR
)
,
the
development
of
mouse
models
of
KSHV
and
oxidative
stress-induced
KS
,
the
identification
of
the
role
of
Rac
1
-
induced
ROS
in
viral
oncogenesis
of
KS
and
the
development
of
novel
therapeutic
approaches
able
to
target
both
latent
and
lytic
oncogenic
KSHV
infection
.
Diseases
Validation
Diseases presenting
"major global health problem"
symptom
primary effusion lymphoma
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