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Criteria for detection of alpha-thalassemia-1 Thai type deletion in routine laboratory.
[alpha-thalassemia]
Using
a
single
tube
multiplex
real-time
PCR
with
SYBR
Green
1
and
high
resolution
melting
(
HRM
)
analysis
in
routine
laboratory
for
detection
of
alpha-thalassemia
-
1
Southeast
Asian
(
SEA
)
type
deletion
simultaneously
with
Thai
type
deletion
is
costly
.
Criteria
for
laboratory
testing
of
alpha-thalassemia
-
1
Thai
type
deletion
were
set
as
follow
:
(
1
)
MCV
<
or
=
75
fL
and
negative
for
alpha-thalassemia
-
1
SEA
type
deletion
,
beta-thalassemia
or
homozygous
HbE
;
(
2
)
HbE
trait
with
HbE
level
<
21
.
5
%
and
negative
for
a-thalassemia-
1
SEA
type
deletion
;
or
(
3
)
Hb
Bart
's
and
HbH
found
on
HPLC
chromatogram
but
negative
for
alpha-thalassemia
-
1
SEA
type
deletion
.
F
rom
May
2010
to
October
2012
,
the
number
of
samples
to
detect
for
alpha-thalassemia
-
1
Thai
type
deletion
decreased
from
15
,
081
to
672
samples
and
the
alpha-thalassemia
-
1
Thai
type
deletion
trait
was
found
in
7
samples
(
1
.
04
%
)
.
The
new
testing
algorithm
can
reduce
number
of
samples
for
detection
of
alpha-thalassemia
-
1
Thai
type
deletion
.
