Rare Diseases Symptoms Automatic Extraction

Castleman's disease and primary effusion lymphoma in a HIV-positive patient.

[primary effusion lymphoma]

We present a case of primary effusion lymphoma (PEL) occurring simultaneously with Castleman's disease in the same patient. Castleman's disease is distinct from PEL, although both are associated with HHV-8. Other cases have debated whether the coexistence of PEL and Castleman's disease is a recurrence of an original PEL tumour in an extracavitary site, or a secondary HHV-8-associated lymphoma distinct from primary PEL. Our case, along with those described previously, show that co-occurrence of PEL and Castleman's disease is possible and plausible. PEL needs to be included in the differential diagnosis in any HIV-positive patient who presents with a pleural effusion, and diagnosis requires only a simple thoracentesis and appropriate immunohistochemistry.

Diseases presenting "pleural effusion" symptom

  • allergic bronchopulmonary aspergillosis
  • cushing syndrome
  • dedifferentiated liposarcoma
  • erdheim-chester disease
  • esophageal carcinoma
  • hydrocephalus with stenosis of the aqueduct of sylvius
  • lymphangioleiomyomatosis
  • pleomorphic liposarcoma
  • primary effusion lymphoma
  • scrub typhus
  • systemic capillary leak syndrome
  • thoracic outlet syndrome
  • waldenström macroglobulinemia
  • wolf-hirschhorn syndrome

This symptom has already been validated