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Human Immunodeficiency Virus (HIV)-Negative and Human Herpes Virus-8 (HHV-8)-Positive Primary Effusion Lymphoma: A Case Report and Review of the Literature.
[primary effusion lymphoma]
Primary
effusion
lymphoma
(
PEL
)
is
a
rare
type
of
non-
Hodgkin
lymphoma
that
presents
with
serosal
effusion
in
body
cavities
,
without
obvious
tumor
masses
.
Although
PEL
occurs
in
immunocompromised
patients
that
are
human
immunodeficiency
virus
(
HIV
)
positive
,
it
also
occurs
in
immunocompetent
human
herpes
virus-
8
(
HHV-
8
)
-
positive
patients
.
Herein
we
present
an
immunocompetent
,
HIV-negative
,
CD-
20
-
negative
,
HHV-
8
-
positive
patient
with
pleural
effusion
that
was
diagnosed
as
PEL
.
The
CHOP
protocol
and
talc
pleurodesis
were
administered
.
HHV-
8
plays
a
causative
role
in
PEL
and
is
important
for
differentiating
PEL
from
other
types
of
lymphoma
.
As
such
,
in
addition
to
pleurodesis
antiviral
treatment
should
be
considered
for
optimal
treatment
outcome
.
None
declared
.
Diseases
Validation
Diseases presenting
"hodgkin lymphoma"
symptom
esophageal adenocarcinoma
hodgkin lymphoma, classical
monosomy 21
primary effusion lymphoma
severe combined immunodeficiency
systemic capillary leak syndrome
waldenström macroglobulinemia
This symptom has already been validated