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Classification of AIDS-related lymphoma cases between 1987 and 2012 in Japan based on the WHO classification of lymphomas, fourth edition.
[primary effusion lymphoma]
The
introduction
of
combined
antiretroviral
therapy
(
ART
)
has
reduced
the
mortality
of
patients
with
human
immunodeficiency
virus-
1
infection
worldwide
.
However
,
malignant
lymphoma
is
a
severe
and
frequent
complication
seen
in
patients
with
acquired
immunodeficiency
syndrome
(
AIDS
)
.
The
diagnostic
criteria
for
some
categories
of
AIDS-related
lymphoma
were
revised
in
the
World
Health
Organization
International
Classification
of
Lymphoma
,
fourth
edition
.
The
purpose
of
this
study
was
to
assess
the
clinicopathological
characteristics
of
Japanese
patients
with
AIDS-related
lymphoma
according
to
the
revised
classification
.
In
this
retrospective
study
,
207
AIDS-related
lymphoma
cases
diagnosed
between
1987
and
2012
in
Japan
were
subjected
to
histological
subtyping
and
clinicopathological
analyses
.
Diffuse
large
B-
cell
lymphoma
(
DLBCL
)
was
the
predominant
histological
subtype
throughout
the
study
period
(
n
=
104
,
50
%
)
.
Among
the
DLBCL
cases
,
24
%
were
of
the
germinal
center
(
GC
)
type
and
76
%
were
of
the
non-
GC
type
.
Non-
GC
-
type
cases
showed
a
significantly
lower
1
-
year
survival
rate
(
43
%
)
than
the
GC
-
type
cases
(
82
%
)
.
Cases
of
Burkitt
lymphoma
(
n
=
57
,
28
%
)
,
plasmablastic
lymphoma
(
n
=
16
,
8
%
)
,
primary
effusion
lymphoma
(
n
=
9
,
4
%
)
,
Hodgkin
lymphoma
(
n
=
8
,
4
%
)
,
and
large
B-
cell
lymphoma
arising
in
Kaposi
sarcoma
-associated
herpesvirus-associated
multicentric
Castleman
disease
(
n
=
2
,
1
%
)
were
also
observed
.
Hodgkin
lymphoma
was
more
common
in
patients
receiving
ART
(
11
.
1
%
)
than
in
ART-naïve
patients
(
1
.
4
%
)
.
Statistical
analyses
identified
CD
10
negativity
,
BCL-
6
negativity
,
Epstein-
Barr
virus
positivity
,
and
Kaposi
sarcoma
-associated
herpesvirus
positivity
as
risk
factors
for
poor
prognosis
.
This
information
will
help
in
the
early
diagnosis
of
lymphoma
in
patients
with
AIDS
.
Diseases
Validation
Diseases presenting
"burkitt lymphoma"
symptom
hodgkin lymphoma, classical
primary effusion lymphoma
waldenström macroglobulinemia
This symptom has already been validated