Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Primary effusion lymphoma: secretome analysis reveals novel candidate biomarkers with potential pathogenetic significance.
[primary effusion lymphoma]
Primary
effusion
lymphoma
(
PEL
)
is
a
rare
B-
cell
neoplasm
in
which
tumor
cells
are
consistently
infected
by
Kaposi
's
sarcoma
-associated
herpesvirus
and
usually
grow
in
body
cavities
without
tumor
mass
formation
.
To
detect
new
proteins
related
to
pathogenesis
,
four
established
cell
lines
from
PEL
(
CRO-
AP
2
,
CRO-
AP
3
,
CRO-
AP
5
,
and
CRO-
AP
6
)
were
characterized
by
proteomics
analysis
of
the
secretome
.
The
secretomes
were
analyzed
using
two
complementary
mass
spectrometry
platforms
:
liquid
chromatography-mass
spectrometry
and
matrix-assisted
laser
desorption
/
ionization
time-of-flight-based
approaches
.
Among
266
proteins
identified
from
the
proteomics
analysis
,
139
were
considered
as
predicted
secreted
.
Twenty
proteins
were
specifically
secreted
by
PEL
cell
lines
after
comparison
with
secretomes
of
human
cell
lines
representative
of
diverse
solid
tumors
and
leukemias
.
More
important
,
27
additional
proteins
were
shared
by
all
CRO-
AP
PEL
cell
lines
.
The
presence
of
these
proteins
was
confirmed
by
IHC
in
CRO-
AP
cell
lines
and
in
six
other
PEL
cell
lines
,
four
PEL
clinical
samples
,
and
three
extracavitary
Kaposi
's
sarcoma
-associated
herpesvirus-
positive
solid
lymphomas
included
for
comparative
analysis
.
Functional
classification
showed
that
PEL
cell
secretomes
were
enriched
in
proteins
specifically
involved
in
inflammation
/
immune
response
,
growth
/
cell
cycle
,
and
mRNA
processing
,
in
addition
to
structural
/
matrix
proteins
and
proteins
with
enzymatic
activity
.
Diseases
Validation
Diseases presenting
"inflammation/immune"
symptom
primary effusion lymphoma
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom