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Systematic analysis of a xenograft mice model for KSHV+ primary effusion lymphoma (PEL).
[primary effusion lymphoma]
Kaposi
's
sarcoma
-associated
herpesvirus
is
the
causative
agent
of
primary
effusion
lymphoma
(
PEL
)
,
which
arises
preferentially
in
the
setting
of
infection
with
human
immunodeficiency
virus
(
HIV
)
.
Even
with
standard
cytotoxic
chemotherapy
,
PEL
continues
to
cause
high
mortality
rates
,
requiring
the
development
of
novel
therapeutic
strategies
.
PEL
xenograft
models
employing
immunodeficient
mice
have
been
used
to
study
the
in
vivo
effects
of
a
variety
of
therapeutic
approaches
.
However
,
it
remains
unclear
whether
these
xenograft
models
entirely
reflect
clinical
presentations
of
KSHV
(
+
)
PEL
,
especially
given
the
recent
description
of
extracavitary
solid
tumor
variants
arising
in
patients
.
In
addition
,
effusion
and
solid
tumor
cells
propagated
in
vivo
exhibit
unique
biology
,
differing
from
one
another
or
from
their
parental
cell
lines
propagated
through
in
vitro
culture
.
Therefore
,
we
used
a
KSHV
(
+
)
PEL
/
BCBL-
1
xenograft
model
involving
non-obese
diabetic
/
severe
-combined
immunodeficient
(
NOD
/
SCID
)
mice
,
and
compared
characteristics
of
effusion
and
solid
tumors
with
their
parent
cell
culture-derived
counterparts
.
Our
results
indicate
that
although
this
xenograft
model
can
be
used
for
study
of
effusion
and
solid
lymphoma
observed
in
patients
,
tumor
cells
in
vivo
display
unique
features
to
those
passed
in
vitro
,
including
viral
lytic
gene
expression
profile
,
rate
of
solid
tumor
development
,
the
host
proteins
and
the
complex
of
tumor
microenvironment
.
These
items
should
be
carefully
considered
when
the
xenograft
model
is
used
for
testing
novel
therapeutic
strategies
against
KSHV-related
lymphoma
.
Diseases
Validation
Diseases presenting
"tumor cells"
symptom
alpha-thalassemia
carcinoma of the gallbladder
cholangiocarcinoma
cushing syndrome
dedifferentiated liposarcoma
dentin dysplasia
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
hodgkin lymphoma, classical
junctional epidermolysis bullosa
kindler syndrome
liposarcoma
lymphangioleiomyomatosis
pleomorphic liposarcoma
primary effusion lymphoma
severe combined immunodeficiency
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
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