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Potent reactive oxygen species-JNK-p38 activation by sodium salicylate potentiates death of primary effusion lymphoma cells.
[primary effusion lymphoma]
Primary
effusion
lymphoma
(
PEL
)
is
a
rare
but
aggressive
form
of
non-
Hodgkin
's
B-
cell
lymphoma
in
immunodeficient
patients
.
Resistance
to
conventional
chemotherapeutic
regimens
is
common
in
PEL
and
contributes
to
a
very
poor
prognosis
;
hence
,
novel
potent
anti-
PEL
agents
are
required
.
Anticancer
effects
of
non-steroidal
anti-
inflammatory
drugs
(
NSAIDs
)
are
well-established
in
epithelial
cancer
but
are
unclear
in
hematological
malignancies
.
Therefore
,
the
anticancer
activities
of
selected
NSAIDs
,
sodium
salicylate
(
NaS
)
,
on
PEL
cell
lines
are
of
interest
.
Anti-proliferation
of
NaS
on
PEL
cell
lines
was
shown
by
MTT
.
Apoptosis
induction
and
caspase
activations
were
determined
by
flow
cytometry
analysis
.
ROS
production
was
accessed
by
DCFH-DA
.
Western
blot
was
performed
to
determine
molecular
mechanisms
.
NaS
effectively
inhibited
cell
proliferation
of
all
PEL
cell
lines
.
Caspase-dependent
apoptosis
was
demonstrated
and
simultaneous
induction
of
reactive
oxygen
species
production
and
c-
Jun
N-
terminal
kinases
(
JNK
)
-
p
38
activation
was
observed
prior
to
apoptosis
induction
,
and
these
might
be
responsible
for
NaS-induced
apoptosis
.
Significant
anticancer
effects
of
NaS
on
PEL
cell
lines
were
found
.
A
novel
role
of
NaS
for
PEL
treatment
is
suggested
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated