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Potent reactive oxygen species-JNK-p38 activation by sodium salicylate potentiates death of primary effusion lymphoma cells.
[primary effusion lymphoma]
Primary
effusion
lymphoma
(
PEL
)
is
a
rare
but
aggressive
form
of
non-
Hodgkin
's
B-
cell
lymphoma
in
immunodeficient
patients
.
Resistance
to
conventional
chemotherapeutic
regimens
is
common
in
PEL
and
contributes
to
a
very
poor
prognosis
;
hence
,
novel
potent
anti-
PEL
agents
are
required
.
Anticancer
effects
of
non-steroidal
anti-
inflammatory
drugs
(
NSAIDs
)
are
well-established
in
epithelial
cancer
but
are
unclear
in
hematological
malignancies
.
Therefore
,
the
anticancer
activities
of
selected
NSAIDs
,
sodium
salicylate
(
NaS
)
,
on
PEL
cell
lines
are
of
interest
.
Anti-proliferation
of
NaS
on
PEL
cell
lines
was
shown
by
MTT
.
Apoptosis
induction
and
caspase
activations
were
determined
by
flow
cytometry
analysis
.
ROS
production
was
accessed
by
DCFH-DA
.
Western
blot
was
performed
to
determine
molecular
mechanisms
.
NaS
effectively
inhibited
cell
proliferation
of
all
PEL
cell
lines
.
Caspase-dependent
apoptosis
was
demonstrated
and
simultaneous
induction
of
reactive
oxygen
species
production
and
c-
Jun
N-
terminal
kinases
(
JNK
)
-
p
38
activation
was
observed
prior
to
apoptosis
induction
,
and
these
might
be
responsible
for
NaS-induced
apoptosis
.
Significant
anticancer
effects
of
NaS
on
PEL
cell
lines
were
found
.
A
novel
role
of
NaS
for
PEL
treatment
is
suggested
.
