Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Short communication: spectrum of non-Hodgkin lymphoma in an urban Ryan White-funded clinic in the established antiretroviral era.
[primary effusion lymphoma]
People
living
with
HIV
/
AIDS
(
PLWHA
)
are
at
a
higher
risk
of
developing
non-
Hodgkin
lymphoma
(
NHL
)
.
The
influence
of
combined
antiretrovirals
(
cART
)
on
the
presentation
,
treatment
,
and
outcomes
of
HIV-associated
NHL
(
HIV-NHL
)
warrants
further
investigation
.
We
performed
a
retrospective
analysis
of
PLWHA
diagnosed
with
NHL
who
received
care
at
the
Infectious
Diseases
Ponce
de
Leon
Center
in
Atlanta
,
Georgia
,
from
January
1
,
2004
to
December
31
,
2010
.
Thirty
-
five
patients
with
HIV-NHL
were
identified
.
Among
these
patients
,
7
had
Burkitt
lymphoma
(
BL
)
,
20
had
diffuse
large
B
cell
lymphoma
(
DLBCL
)
,
7
had
plasmablastic
lymphoma
(
PL
)
,
and
1
had
primary
effusion
lymphoma
(
PEL
)
.
The
majority
of
patients
(
82
.
9
%
)
presented
with
advanced
disease
,
and
63
%
were
not
on
ART
at
diagnosis
.
Despite
having
good
performance
status
at
presentation
,
the
majority
of
patients
presented
with
high
International
Prognostic
Index
(
IPI
)
scores
.
There
were
differences
between
the
histologic
subtypes
of
NHL
in
regard
to
treatment
,
complications
,
and
outcomes
.
The
median
CD
4
lymphocyte
count
at
diagnosis
was
110
cells
/
mm
(
3
)
for
patients
with
DLBCL
[
interquartile
range
(
IQR
)
:
66
,
203
]
,
165
cells
/
mm
(
3
)
for
Burkitt
lymphoma
(
IQR
:
36
,
199
)
,
and
98
cells
/
mm
(
3
)
for
plasmablastic
lymphoma
(
IQR
:
34
,
214
)
.
Overall
,
patients
completed
67
%
of
planned
chemotherapy
cycles
.
Common
causes
for
chemotherapy
termination
were
persistent
myelosuppression
(
18
.
2
%
)
,
social
factors
(
22
.
7
%
)
,
and
disease
progression
(
36
.
4
%
)
.
Social
factors
included
lack
of
transportation
,
substance
abuse
,
unstable
housing
,
and
poor
adherence
.
Two
-
year
overall
survival
was
40
%
for
all
HIV-NHL
.
Half
of
the
patients
with
DLBCL
(
n
=
10
)
,
42
%
of
patients
with
PL
(
n
=
3
)
,
and
only
14
.
3
%
of
patients
with
BL
(
n
=
1
)
were
alive
at
2
years
.
Among
the
overall
survivors
at
2
years
,
85
.
7
%
had
CD
4
>
200
cells
/
mm
(
3
)
and
78
.
6
%
had
undetectable
HIV
viral
loads
(
VL
)
at
that
time
.
Diseases
Validation
Diseases presenting
"hodgkin lymphoma"
symptom
esophageal adenocarcinoma
hodgkin lymphoma, classical
monosomy 21
primary effusion lymphoma
severe combined immunodeficiency
systemic capillary leak syndrome
waldenström macroglobulinemia
This symptom has already been validated
