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Efficacy of anti-CD47 antibody-mediated phagocytosis with macrophages against primary effusion lymphoma.
[primary effusion lymphoma]
Recently
,
the
critical
role
of
CD
47
on
the
surface
of
resistant
cancer
cells
has
been
proposed
in
their
evasion
of
immunosurveillance
.
Primary
effusion
lymphoma
(
PEL
)
is
a
subtype
of
aggressive
non-
Hodgkin
lymphoma
that
shows
serous
lymphomatous
effusion
in
body
cavities
,
especially
in
advanced
acquired
immunodeficiency
syndrome
(
AIDS
)
.
PEL
is
resistant
to
conventional
chemotherapy
and
has
a
poor
prognosis
.
In
this
study
,
we
evaluated
the
effect
of
anti-
CD
47
antibody
(
Ab
)
on
PEL
in
vitro
and
in
vivo
.
Surface
CD
47
of
PEL
cell
lines
was
examined
by
flow
cytometry
.
Efficacy
of
knocking
down
CD
47
or
anti-
CD
47
Ab
-mediated
phagocytosis
against
PEL
was
evaluated
using
mouse
peritoneal
macrophages
and
human
macrophages
in
vitro
.
Primary
PEL
cells
were
injected
intraperitoneally
into
NOD
/
Rag
-
2
/
Jak
3
double
-
deficient
(
NRJ
)
mice
to
establish
a
direct
xenograft
mouse
model
.
Surface
CD
47
of
PEL
cell
lines
was
highly
expressed
.
Knocking
down
CD
47
and
anti-
CD
47
Ab
promoted
phagocytic
activities
of
macrophages
in
a
CD
47
expression-dependent
manner
in
vitro
.
Treatment
with
anti-
CD
47
Ab
inhibited
ascite
formation
and
organ
invasion
completely
in
vivo
compared
with
control
IgG-treated
mice
.
CD
47
plays
the
pivotal
role
in
the
immune
evasion
of
PEL
cells
in
body
cavities
.
Therapeutic
antibody
targeting
of
CD
47
could
be
an
effective
therapy
for
PEL
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated
