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Human herpesvirus 8 viral interleukin-6 signaling through gp130 promotes virus replication in primary effusion lymphoma and endothelial cells.
[primary effusion lymphoma]
The
contributions
of
human
herpesvirus
8
(
HHV-
8
)
viral
interleukin-
6
(
vIL-
6
)
to
virus
biology
remain
unclear
.
Here
we
examined
the
role
of
vIL-
6
/
gp
130
signaling
in
HHV-
8
productive
replication
in
primary
effusion
lymphoma
and
endothelial
cells
.
Depletion
and
depletion
-complementation
experiments
revealed
that
endoplasmic
reticulum-
localized
vIL-
6
activity
via
gp
130
and
gp
130
-
activated
signal
transducer
and
activator
of
transcription
(
STAT
)
signaling
,
but
not
extracellular
signal-regulated
kinase
(
ERK
)
activation
,
was
critical
for
vIL-
6
proreplication
activity
.
Our
data
significantly
extend
current
understanding
of
vIL-
6
function
and
associated
mechanisms
in
HHV-
8
biology
.
Diseases
Validation
Diseases presenting
"endoplasmic reticulum-localized vil-6"
symptom
primary effusion lymphoma
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