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Sustained complete remission of primary effusion lymphoma with adjunctive ganciclovir treatment in an HIV-positive patient.
[primary effusion lymphoma]
Primary
effusion
lymphoma
(
PEL
)
is
one
of
the
least
common
of
the
AIDS-related
lymphomas
,
accounting
for
less
than
1
-
4
%
of
cases
.
Clinical
manifestations
depend
on
the
extent
and
distribution
of
disease
and
,
as
in
the
majority
of
patients
no
detectable
mass
lesion
is
found
,
symptoms
are
related
to
fluid
accumulation
,
dyspnoea
(
pleural
or
pericardial
effusions
)
,
abdominal
distension
(
ascites
)
or
joint
swelling
.
The
median
survival
after
diagnosis
,
even
with
aggressive
chemotherapy
,
remains
poor
and
remissions
are
often
of
short
duration
.
We
present
the
case
of
a
31
-
year
-old
man
with
AIDS
and
diagnosis
of
PEL
,
in
whom
sustained
and
complete
remission
of
the
tumour
was
achieved
with
adjunctive
ganciclovir
therapy
.
Since
the
disease
is
so
uncommon
,
there
is
a
paucity
of
data
to
guide
the
treatment
of
these
patients
;
ganciclovir
might
be
a
potential
antiviral
therapeutic
option
,
as
demonstrated
by
the
2
-
year
remission
achieved
in
our
patient
.
Diseases
Validation
Diseases presenting
"pericardial effusions"
symptom
primary effusion lymphoma
This symptom has already been validated
