Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Diverse clinicopathologic features in human herpesvirus 8-associated lymphomas lead to diagnostic problems.
[primary effusion lymphoma]
Human
herpesvirus
8
(
HHV
8
)
-
associated
lymphomas
are
uncommon
,
mainly
affect
men
infected
with
the
human
immunodeficiency
virus
(
HIV
)
,
and
usually
have
a
poor
prognosis
.
We
sought
to
characterize
the
HHV
8
+
lymphomas
seen
at
our
institution
since
the
mid-
1990
s
.
We
identified
15
patients
with
HHV
8
-
associated
lymphomas
and
evaluated
their
clinical
and
pathologic
features
.
Diagnoses
included
primary
effusion
lymphoma
(
PEL
)
(
n
=
2
)
,
extracavitary
PEL
(
n
=
8
)
,
intravascular
large
B-
cell
lymphoma
(
n
=
1
)
,
HHV
8
+
plasmablastic
microlymphoma
(
n
=
3
)
,
and
germinotropic
lymphoproliferative
disorder
(
GLD
)
(
n
=
1
)
.
The
case
of
GLD
progressed
to
a
high
-grade
HHV
8
+
Epstein-
Barr
virus-
positive
lymphoma
,
an
evolution
that
has
not
been
previously
reported
.
Four
patients
were
HIV-
(
three
from
an
HHV
8
-
endemic
area
)
.
Potentially
misleading
pathologic
features
in
our
series
of
extracavitary
PEL
included
classic
Hodgkin
lymphoma
-like
features
,
lymph
node
sinus
involvement
,
and
T
-
cell
antigen
expression
.
H
HV
8
-
associated
lymphomas
can
be
clinically
and
pathologically
heterogeneous
,
with
features
that
may
lead
to
misdiagnosis
as
other
types
of
lymphoma
.
Diseases
Validation
Diseases presenting
"immunodeficiency"
symptom
adrenal incidentaloma
allergic bronchopulmonary aspergillosis
cushing syndrome
dracunculiasis
hirschsprung disease
hodgkin lymphoma, classical
homocystinuria without methylmalonic aciduria
kabuki syndrome
legionellosis
malignant atrophic papulosis
oculocutaneous albinism
omenn syndrome
papillon-lefèvre syndrome
primary effusion lymphoma
primary hyperoxaluria type 1
pyomyositis
severe combined immunodeficiency
sneddon syndrome
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated