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Efficiency of recombinant erythropoietin administration in hemoglobinopathy H.
[alpha-thalassemia]
Alpha-thalassemia
is
widely
spread
in
human
population
and
one
of
the
most
common
types
of
α-thalassemia
is
hemoglobinopathy
H
which
develops
with
mild
microcytic
hypochromic
anemia
,
hepatosplenomegaly
and
jaundice
.
The
basic
method
of
anemia
correction
is
blood
transfusion
.
However
this
method
has
crucial
deficiencies
.
As
it
is
known
recombinant
erythropoetin
(
rEPO
)
contributes
to
erythroid
proliferation
and
could
be
used
for
anemia
treatment
.
The
aim
of
the
study
was
to
qualify
efficiency
of
administration
rEPO
in
complex
therapy
of
hemaglobinopathy
H
.
Study
involved
irregularly
transfused
14
patients
with
hemoglobinopathy
H
(
2
males
and
12
females
)
.
Control
group
included
30
healthy
persons
.
Recombinant
erythropoietin
(
Eprex
)
administrated
hypodermically
10
,
000
units
3
times
a
week
during
6
months
.
Average
hemoglobin
level
before
treatment
was
62
g
/
l
.
Responses
to
the
rEPO
treatment
varied
from
9
to
70
g
/
l
,
9
(
64
%
)
of
patients
had
a
good
response
,
showed
an
increase
in
hemoglobin
level
more
than
20
g
/
l
.
In
4
patients
(
29
%
)
had
a
moderate
response
(
10
-
20
g
/
l
)
,
but
only
in
1
(
7
%
)
patient
occurred
poor
response
.
Changing
the
parameters
of
erithrocyte
indices
,
hemoglobin
fractions
,
serum
iron
and
serum
ferritin
level
are
not
statistically
significant
.
It
can
be
concluded
that
the
use
of
rEPO
in
complex
therapy
of
hemaglobinopathy
H
,
leads
to
increased
levels
of
hemoglobin
and
consequently
reducing
the
need
for
blood
transfusions
.
Diseases
Validation
Diseases presenting
"known recombinant erythropoetin (repo"
symptom
alpha-thalassemia
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