Liposarcoma of the oral cavity--case reports of the pleomorphic and the dedifferentiated variants and a review of the literature.

[pleomorphic liposarcoma]

Liposarcoma is one of the commonest soft -tissue sarcomas , but very rare in the oral cavity . We present two cases of liposarcoma of the oral cavity , together with the related clinical , histopathological and immunohistochemical findings : one affecting the cheek of a 62 -year -old man and the other the gingival maxillary tuber of a 41 -year -old woman . At histological examination a diagnosis of liposarcoma was made in both cases . In the first case , immunohistochemical analysis revealed intense positivity for p 53 , MIB-1 , MDM 2 , and focal positivity for S 100 protein and CD 34 , but was negative for alpharsmooth muscle actin , desmin and CD 68 . The second case it was intensely positive for p 53 , MIB-1 , S-100 , and focal positive for MDM 2 , but negative for alpha smooth muscle actin , CD 34 , CD 68 and desmin . Histological examination and immunohistochemical profiles in the first case were consistent with pleomorphic liposarcoma , whilst that in the second case with dedifferentiated liposarcoma . Both patients were subjected to surgical treatment with wide surgical margins , without adjuvant radio- or chemotherapy . The first case was lost at follow-up one year after surgery , while the second case has not undergone relapse after seven years . We discuss differential diagnosis , examining the histopathological and immunohistochemical features that are potentially useful for distinguishing this tumor from other malignant adipose tissue tumors .

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pleomorphic liposarcoma

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