Myxoid/round cell and pleomorphic liposarcomas: prognostic factors and survival in a series of patients treated at a single institution.

[pleomorphic liposarcoma]

The objective of this study was to investigate prognostic factors and clinical outcome of myxoid /round cell and pleomorphic liposarcoma .Three hundred twenty-nine patients with localized myxoid /round cell or pleomorphic liposarcoma who underwent surgery at the Istituto Nazionale per lo Studio e la Cura dei Tumori (Milan , Italy ) over 25 years were reviewed . The rates of local recurrence , distant metastases , and survival were studied .Two hundred fourteen patients presented with primary disease , and 115 patients had locally recurrent tumors . The disease-specific survival rate was 75 % at 10 years , and the local recurrence and distant metastases incidence were 25 % and 15 %, respectively . Presentation with recurrent disease , tumor size (>10 cm ), tumor grade (French Federation of Cancer Centers grade II or III vs grade I ), and positive surgical margins were independent predictors of death . Tumor site and radiation therapy also played a role , mostly related to their effect on local outcome . Pathologic grade and histologic subtype influenced distant metastases . Extrapulmonary metastases were associated with poorer postmetastatic disease-specific survival .Myxoid /round cell liposarcomas shared similar prognostic factors with other soft tissue sarcomas and had a relatively good clinical outcome . The presence of >5 % of round cell component singled out a group of patients at greater risk of metastases and death but with a broad spectrum of disease aggressiveness . Extrapulmonary metastases were a peculiar pattern of myxoid /round cell liposarcoma that require special consideration for treatment and prognosis .

Diseases
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Diseases presenting "localized myxoid/round cell" symptom

pleomorphic liposarcoma

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