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Rare t(1;11)(q23;p15) in therapy-related myelodysplastic syndrome evolving into acute myelomonocytic leukemia: a case report and review of the literature.
[pleomorphic liposarcoma]
Balanced
chromosome
rearrangements
are
the
hallmark
of
therapy-related
leukemia
that
develops
in
patients
treated
with
topoisomerase
II
inhibitors
.
Many
of
these
rearrangements
involve
recurrent
chromosomal
sites
and
associated
genes
(
11
q
23
/
MLL
,
21
q
22
.
3
/
AML
1
,
and
11
p
15
/
NUP
98
)
,
which
can
interact
with
a
variety
of
partner
genes
.
One
such
rearrangement
is
the
rare
t
(
1
;
11
)
(
q
23
;
p
15
)
,
which
involves
juxtaposition
of
the
homeobox
gene
PMX
1
(
PRRX
1
)
and
NUP
98
.
We
report
on
an
additional
patient
with
t
(
1
;
11
)
who
presented
with
myelodysplastic
syndrome
(
MDS
)
subsequent
to
treatment
for
a
pleomorphic
liposarcoma
.
With
time
,
the
patient
's
disorder
progressed
to
acute
myelomonocytic
leukemia
with
cytogenetic
evidence
of
clonal
evolution
.
To
our
knowledge
,
this
is
the
first
report
of
a
patient
presenting
with
a
myelodysplastic
syndrome
with
isolated
t
(
1
;
11
)
(
q
23
;
p
15
)
,
which
evolved
into
therapy-related
acute
myeloid
leukemia
(
t-
AML
)
.
This
patient
is
the
third
reported
with
this
cytogenetic
rearrangement
and
t-
AML
,
and
is
compared
with
the
other
two
reports
of
t
(
1
;
11
)
(
q
23
;
p
15
)
.
