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Mesenchymal neoplasms of the major salivary glands: clinicopathological features of 18 cases.
[pleomorphic liposarcoma]
Non-lymphoid
mesenchymal
neoplasms
of
salivary
gland
origin
are
rare
,
accounting
for
1
.
9
-
5
%
of
major
salivary
gland
tumors
.
We
describe
the
clinico-pathologic
features
of
18
cases
of
mesenchymal
neoplasms
of
the
major
salivary
glands
experienced
at
Asan
Medical
Center
,
Seoul
,
Korea
,
from
1998
to
2004
.
Mesenchymal
neoplasms
accounted
for
3
.
4
%
of
the
total
of
524
major
salivary
gland
tumors
.
The
parotid
gland
was
the
preponderant
site
(
15
cases
)
.
Thirteen
tumors
were
benign
,
constituting
3
.
5
%
of
the
total
of
371
benign
neoplasms
.
Schwannomas
were
the
most
common
benign
tumors
(
six
cases
)
,
followed
by
lipomas
(
three
cases
)
,
plexiform
neurofibroma
,
hemangioma
,
desmoid
tumor
,
and
solitary
fibrous
tumor
(
one
each
)
.
The
malignant
tumors
consisted
of
one
dermatofibrosarcoma
protuberans
,
synovial
sarcoma
,
leiomyosarcoma
,
pleomorphic
liposarcoma
and
desmoplastic
small
round
cell
tumor
each
.
Immunohistochemical
analysis
for
the
expression
of
vimentin
,
actin
,
desmin
,
neuron-
specific
enolase
,
keratin
,
CD
34
,
CD
99
and
bcl-
2
contributed
to
the
differential
diagnoses
.
Genetic
analysis
for
fusion
transcripts
was
conclusive
in
the
diagnosis
of
desmoplastic
small
round
cell
tumor
,
which
is
extremely
rare
at
this
location
.
Pre-operative
imaging
study
and
fine
needle
aspiration
cytology
had
limitations
in
prediction
of
the
mesenchymal
nature
of
the
tumors
,
due
to
either
low
index
of
suspicion
,
similarities
to
mixed
tumors
,
or
specimen
inadequacy
.
Awareness
of
the
development
of
various
mesenchymal
tumors
in
the
major
salivary
glands
could
increase
the
accuracy
of
preoperative
and
postoperative
diagnosis
,
and
therapeutic
efficacy
.
Diseases
Validation
Diseases presenting
"synovial sarcoma"
symptom
dedifferentiated liposarcoma
liposarcoma
pleomorphic liposarcoma
well-differentiated liposarcoma
This symptom has already been validated
