Dedifferentiated liposarcoma with leukocytosis. A case report of G-CSF-producing soft-tissue tumors, possible association with undifferentiated liposarcoma lineage.

[pleomorphic liposarcoma]

Granulocyte-colony-stimulating factor (G-CSF ) functions as a hematopoietic growth factor and it is responsible for leukocytosis . G-CSF-producing tumors associated with leukocytosis include various types of malignancies .We report the case of a 72 -year -old man with dedifferentiated liposarcoma characterized by dedifferentiated components of malignant fibrous histiocytoma (MFH )-like features in addition to well-differentiated lipoma -like liposarcoma , arising from his upper arm . Preoperative laboratory data showed leukocytosis (103 ,700 /mul ). The serum level of G-CSF was also elevated (620 pg /ml [normal , <8 pg /ml ]). Nine days after the surgery , the leukocytosis was relieved (WBC ; 6 ,920 /mul ) and the elevated serum G-CSF level was significantly decreased (G-CSF ; 12 pg /ml ). One month after the surgery , leukocytosis gradually began to appear again . Three months after the surgery metastatic lung lesions were confirmed , and the patient subsequently died of respiratory problems . In the English literature regarding soft -tissue tumors with leukocytosis , including the current case , we could review a total of 6 cases of liposarcoma with leukocytosis . The subtype of these 6 liposarcoma cases was undifferentiated liposarcoma , comprising dedifferentiated liposarcoma in 4 cases and pleomorphic liposarcoma in 2 cases .Since the only other soft -tissue tumor that was associated with leukocytosis was MFH , and since MFH is characterized by the absence of any specific differentiation , we would like to propose a possible association between G-CSF-producing soft -tissue tumors and an undifferentiated liposarcoma lineage , such as dedifferentiated liposarcoma or pleomorphic liposarcoma .

Diseases
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Diseases presenting "well-differentiated lipoma-like liposarcoma" symptom

pleomorphic liposarcoma

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