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Primary mediastinal liposarcoma: clinicopathologic analysis of 24 cases.
[pleomorphic liposarcoma]
Liposarcomas
are
rare
in
the
mediastinum
.
Here
,
we
report
the
clinicopathologic
features
of
24
cases
of
mediastinal
liposarcoma
.
Patients
included
13
males
and
11
females
,
with
an
age
range
of
3
to
72
years
(
median
58
)
.
Nine
tumors
were
located
in
the
anterior
mediastinum
,
7
in
the
posterior
mediastinum
,
1
in
the
superior
mediastinum
,
and
the
precise
location
was
not
specified
in
7
cases
.
Of
the
anterior
mediastinal
tumors
,
3
appeared
to
arise
from
the
thymus
.
Tumors
were
well-circumscribed
,
multinodular
masses
and
ranged
in
size
from
2
.
2
to
61
cm
in
greatest
dimension
(
median
16
cm
)
.
Histologic
examination
revealed
that
most
of
the
cases
were
well-differentiated
liposarcomas
(
10
)
,
followed
by
dedifferentiated
liposarcomas
(
8
)
,
pleomorphic
liposarcomas
(
4
)
,
and
myxoid
liposarcomas
(
2
)
.
Of
the
pleomorphic
liposarcomas
,
2
had
areas
that
resembled
myxofibrosarcoma
with
atypical
hyperchromatic
spindle
cells
in
a
myxoid
stroma
,
but
the
focal
presence
of
lipoblasts
confirmed
the
diagnoses
.
Clinical
follow-up
was
obtained
in
15
cases
(
range
1
to
59
mo
;
median
26
)
.
Complete
surgical
excision
was
attempted
in
13
patients
;
however
,
local
recurrence
was
common
(
5
cases
)
,
including
1
patient
whose
tumor
recurred
twice
.
Eleven
patients
were
alive
with
no
evidence
of
disease
at
last
follow-up
(
5
well-differentiated
,
5
dedifferentiated
,
and
1
myxoid
liposarcoma
)
.
Two
patients
developed
distant
metastases
(
dedifferentiated
and
pleomorphic
liposarcoma
)
.
One
patient
was
alive
with
disease
(
pleomorphic
liposarcoma
)
,
and
2
died
of
disease
(
pleomorphic
and
dedifferentiated
liposarcoma
)
.
Overall
,
mediastinal
liposarcomas
appear
to
be
similar
,
in
clinicopathologic
terms
,
to
liposarcomas
arising
in
the
retroperitoneum
.
Diseases
Validation
Diseases presenting
"myxoid liposarcoma"
symptom
dedifferentiated liposarcoma
liposarcoma
pleomorphic liposarcoma
well-differentiated liposarcoma
This symptom has already been validated
