Soft tissue sarcomas with complex genomic profiles.

[pleomorphic liposarcoma]

Soft tissue sarcomas (STS ) with complex genomic profiles (50 % of all STS ) are predominantly composed of spindle cell /pleomorphic sarcomas , including leiomyosarcoma , myxofibrosarcoma , pleomorphic liposarcoma , pleomorphic rhabdomyosarcoma , malignant peripheral nerve sheath tumor , angiosarcoma , extraskeletal osteosarcoma , and spindle cell /pleomorphic unclassified sarcoma (previously called spindle cell /pleomorphic malignant fibrous histiocytoma ). These neoplasms show , characteristically , gains and losses of numerous chromosomes or chromosome regions , as well as amplifications . Many of them share recurrent aberrations (e .g ., gain of 5 p 13 -p 15 ) that seem to play a significant role in tumor progression and /or metastatic dissemination . In this paper , we review the cytogenetic , molecular genetic , and clinicopathologic characteristics of the most common STS displaying complex genomic profiles . Features of diagnostic or prognostic relevance will be discussed when needed .

Diseases
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Diseases presenting "called spindle cell/pleomorphic malignant fibrous histiocytoma" symptom

pleomorphic liposarcoma

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