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Significance of LRP and PPAR-gamma Expression in Lipomatous Soft Tissue Tumors.
[pleomorphic liposarcoma]
Molecular
mechanism
of
differentiation
in
lipogenic
tumor
is
still
unknown
in
detail
.
Low
-density
lipoprotein
receptor-related
protein
(
LRP
)
and
peroxisome
proliferator-activated
receptor
gamma
(
PPAR-gamma
)
,
representative
regulatory
molecules
of
lipogenic
differentiation
,
have
been
reported
today
as
multi-
functional
molecules
and
to
modulate
tumorigenesis
in
various
kind
of
cancer
.
To
date
,
diagnostic
and
therapeutic
significance
of
the
expression
of
these
molecules
in
lipogenic
tumors
are
not
defined
.
The
immunohistochemical
expression
status
of
LRP
and
PPAR-gamma
in
various
grades
of
54
lipogenic
tumors
was
analyzed
.
Correlation
between
the
expression
levels
and
the
differentiation
of
the
tumors
was
confirmed
.
For
statistical
analyses
,
the
Kruskal-
Wallis
test
,
the
Steel-
Dwass
test
and
the
Mann-
Whitney
U
test
were
used
.
LRP
and
PPAR-gamma
expression
was
detected
in
50
(
92
.
6
%
)
and
44
(
81
.
5
%
)
cases
,
respectively
.
The
expression
level
in
LRP
was
significantly
higher
in
cases
with
well
differentiated
liposarcoma
,
pleomorphic
liposarcoma
and
dedifferentiated
liposarcoma
than
in
lipoma
.
Compared
with
lipoma
or
well
differentiated
liposarcoma
,
significant
elevation
in
expression
level
of
PPAR-gamma
was
confirmed
in
myxoid
liposarcoma
,
pleomorphic
liposarcoma
,
dedifferentiated
liposarcoma
and
the
differentiated
area
of
dedifferentiated
liposarcoma
.
The
up-regulation
of
LRP
and
PPAR-gamma
in
higher
grade
cases
,
i
.
e
.
less
differentiated
tumors
than
in
low
grade
cases
was
shown
,
suggesting
the
candidate
role
of
these
molecules
as
tumor
progression
modulators
rather
than
regulatory
molecules
of
differentiation
in
lipogenic
tumors
.
Diseases
Validation
Diseases presenting
"liposarcoma"
symptom
dedifferentiated liposarcoma
erdheim-chester disease
focal myositis
gm1 gangliosidosis
liposarcoma
pleomorphic liposarcoma
well-differentiated liposarcoma
This symptom has already been validated
